MOTS-c

Scientific Data

CAS Number

1627580-64-6

Molecular Formula

C₁₀₀H₁₆₂N₃₄O₃₂S

Molecular Weight

2174.64 g/mol

Aliases

Mitochondrial Open Reading Frame of the 12S rRNA-c

Category

Other

Description

MOTS-c is a 16 amino acid mitochondria-derived peptide encoded within the 12S ribosomal RNA gene of the mitochondrial genome. It is one of a small number of peptides known to be encoded by mitochondrial rather than nuclear DNA. Research has focused on its role in metabolic regulation, particularly its effects on AMPK pathway activation, glucose uptake, and insulin sensitivity. Studies have examined its role in mitochondrial biogenesis, cellular stress response, and age-related metabolic decline, positioning it as one of the most studied mitochondrial peptides in longevity research. It is supplied in lyophilised form for research purposes.