Dihexa

Scientific Data

CAS Number

1191588-00-7

Molecular Formula

C₂₄H₄₀N₄O₄

Molecular Weight

452.61 g/mol

Aliases

N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, PNB-0408

Category

Cognitive

Description

Dihexa is a synthetic heptapeptide analogue derived from angiotensin IV, designed to cross the blood-brain barrier and act as a potent hepatocyte growth factor (HGF) agonist at the MET receptor. Research has focused on its role in synaptogenesis, dendritic spine formation, and cognitive function in the context of neurodegenerative disease models. Studies have identified it as one of the most potent pro-cognitive compounds examined in preclinical research, with activity at concentrations significantly lower than other nootropic peptides. It is supplied in lyophilised form for research purposes.